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KMID : 0043320060290121119
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Archives of Pharmacal Research
2006 Volume.29 No. 12 p.1119 ~ p.1124
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Monoamine Oxidase Inhibitory Coumarins from the Aerial Parts of Dictamnus albus
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Jung Sun-Hwa
Han Xiang Hua
Hong Seong-Soo
Hwang Ji-Sang
Hwang Ji-Hye
Lee Dong-Ho
Lee Myung-Koo
Ro Jai-Seup
Hwang Bang-Yeon
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Abstract
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The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6’R-hydroxy-3’, 7’-dimethyl-2’E, 7’-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with values of 0.7 and , respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B () compared to MAO-A (). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.
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KEYWORD
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us albus, Rutaceae, Coumarin, Monoamine oxidase inhibitor
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